This is an easy low-carb and carnivore breakfast that can be prepared with less than 5 ingredients in just a few minutes!
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This is an easy low-carb and carnivore breakfast that can be prepared with less than 5 ingredients in just a few minutes!
This cheesy dip is perfect for any dinner party, game night or the next Super Bowl. You can use any blue cheese you like — Danish Blue, Stilton, Roquefort or even softer Gorgonzola will work well.
Make a batch in juts five minutes and serve it with crispy Buffalo Chicken Wings or crunchy vegetables such as carrots, bell peppers or celery sticks.
You can also serve this dip with any keto crackers like these Crispy Multiseed Keto Crackers or some pepperoni crisps for a tasty carnivore snack. To make the pepperoni crisps, I included some tips below. Enjoy!
Hands-on: 5 minutes
Overall: 5 minutes
Total Carbs | 0.9 | grams |
Fiber | 0 | grams |
Net Carbs | 0.8 | grams |
Protein | 3 | grams |
Fat | 9.3 | grams |
of which Saturated | 3.8 | grams |
Energy | 98 | kcal |
Magnesium | 4 | mg (1% RDA) |
Potassium | 47 | mg (2% EMR) |
Macronutrient ratio: Calories from carbs (3%), protein (12%), fat (85%)
New study shows that LDL cholesterol elevation on a low-carb diet is associated with leanness and metabolic health (low triglyceride to HDL ratio).
Those individuals with the most extreme low-carb lipid triad (LDL ≥ 200, HDL ≥80, TG ≤ 70) are termed “Lean Mass Hyper-Responders and, true to their name, they were significantly leaner than other participants.
Moderate reintroduction of carbohydrate (50 - 100 grams) on very low-carb diets markedly lowers LDL in Lean Mass Hyper-Responders.
To quote my colleague, Dr. Adrian Soto-Mota, MD PhD, “This study is intended to start a discussion, not end one.”
The final version of the Lean Mass Hyper-Responder (LMHR) paper was just released!
I’m pleased to report that, even in the early days since the initial release of the unedited accepted manuscript (on November 30, 2021), this paper has stimulated vigorous discussion, risen to the top of its journal for all time reads, and is among the top 15 trending papers across all American Society of Nutrition associated journals for the year 2021. So, what’s all the fuss about? This blog is intended to get you up to speed so you can be part of the discussion and follow this exciting line of biomedical research as the conversation continues to heat up.
Let’s start at the beginning. In 2017, a software engineer, Dave Feldman, made a curious observation: the people who adopted carbohydrate restricted diets who typically exhibited the most pronounced increases of LDL cholesterol (so-called “bad cholesterol”) were often very lean and/or athletic.
But the elevations in LDL exhibited by these lean persons on low-carb diets had two peculiar features that set it apart from other forms of high LDL:
First, the LDL increases were much larger than those typically associated with living an unhealthy lifestyle. When most doctors think about high LDL related to being unhealthy and eating a poor diet, they think about levels in the high 100s. But lean people on carbohydrate restricted diets were anecdotally observing LDL levels of 200, 300, 400, and even 500 mg/dL or more.
In fact, some LMHRs exhibit LDL levels as high as persons with homozygous familial hypercholesterolemia, a rare and devastating genetic condition (1 in 1,000,000) that likewise associates with very early heart disease.
Second, when lean people do see increases in LDL on a carbohydrate restricted diets, they tend to be accompanied by high HDL (so-called "good cholesterol") and low triglycerides (TG), fat in the blood. This pattern of high HDL and low TG is exactly opposite the profile of “atherogenic dyslipidemia,” which is defined by low HDL and high TG, and is, at present, the predominant risk factor for cardiovascular disease ( Libby, 2021).
Simply put, when lean people on low-carbohydrate diets saw increases in LDL they were quite often in the context of otherwise excellent metabolic health markers. Therefore, Dave created a set of three cut points that combine to define what would become the LMHR phenotype:
Now for a couple comments on the definition of LMHR. First, why these cut points? Well, in addition to approximating threshold levels Dave Feldman was empirically observing in the world around him for lean athletic people who went low-carb, these triad of cut-points were chosen for just how extreme they are.
To meet someone with LDL ≥ 200 is rare. To meet someone with HDL ≥ 80 is rare, and to meet someone with TG ≤ 70 is rare. Thus, the probability of meeting someone who meets all the cut points by chance is highly unlikely. Otherwise put, if someone presents with this triad, it seems reasonable to hypothesize that the markers are associated with each other.
Other important point is that LMHR are only defined by this triad, and NOT by any measure of leanness. This is confusing because “lean” is in the name of the phenotype, but that’s only because the triad — at least in Dave’s point of view in 2017 – tended to occur in people who were lean and/or athletic. In other words, the name LMHR is the hypothesis — that this triad presents in lean people who go low-carb.
It was a long time coming, but we finally put that hypothesis to the test in a scientific study.
In this new study, published in Current Developments in Nutrition, we collected survey data from people who were low-carb, who were not on statins, and who had lipid data from before they started their low-carb diet as well as recent lipid data from on their low-carb diet.
Then, rather than massaging the numbers to conform to our hypothesis, we engaged in a “hypothesis-naïve exploratory analysis” in which we took all the data we had on respondents — including age, sex, BMI, and current and pre-low carb LDL, HDL, and TG levels — and asked a computer to tell us which factors were most strongly and reliably associated with increases in LDL after starting a low-carb diet.
The results were clear. No matter how we approached the question (be it multivariate linear regressions or hypothesis-naïve computer-generated decision trees [Supplemental Figure 3]) we found that having lower BMI and a lower TG/HDL ratio associated with larger increases in LDL.
Hypothesis-naïve exploratory analysis finds that having lower BMI and a lower TG/HDL ratio associates with larger increases in LDL on a low-carbohydrate diet.
The relationship can be clearly seen in the bar graph below. The further you go to the left, the lower the BMI. The further you go to the back, the lower the pre-diet TG/HDL ratio. And the height of the bar is the median increase in LDL.
After establishing that those who are leaner with lower TG/HDL ratios exhibited larger increases in LDL with carbohydrate restriction, it made sense to try to separate the true LMHR (those who met all three cut-points) from the larger cohort and see how different they really were…
Of the 548 participants that met the inclusion criteria, 100 were bona fide LMHR (which is a lot, considering many people don’t believe LMHR exist). And, true to their name, they were Lean!
The average BMI of a LMHR was 22.0, as compared to 24.6 for the rest of the low-carb sample in this study (between group p = 1.2 x 10-10). Furthermore, LMHR exhibited higher LDL, higher HDL, and lower TG, with mean values of 320, 99, and 47 mg/dL respectively.
And, importantly, LMHR did not differ in terms of their pre-diet LDL when compared to the non-LMHR population. In fact, median pre-diet LDL was 135 mg/dL in non-LMHR and 133 mg/dL in LMHR. No difference!
In the Lean Mass Hyper-Responders (LMHR) paper, the average LDL, HDL, and TG of LMHR were 320, 99, and 47 mg/dL on low-carb, respectively. This was despite normal pre-diet LDL levels.
Now, you’ve probably sensed a lot of enthusiasm from me, but don’t mistake intellectual excitement about a fascinating observation for a suggestion that high LDL levels in LMHR are benign.
Setting my own hypotheses aside, we do not yet know if the risk associated with high LDL is any different in the context of LMHR as compared to any other context. And most experts would agree that high LDL is dangerous, regardless of cause.
This very question — is high LDL harmful in LMHR? — is currently being assessed in a prospective study (data from which are expected to drop in 2023). And I will be vocal about the data when they emerge, whatever they say.
Nevertheless, for the time being, many or most LMHR patients and their doctors are concerned about their high LDL. That said, many of those same people find a low-carb way of life to be tremendously beneficial for their various metabolic disorders. This begs the question, can you “fix” the LDL problem (perceived or true) through lifestyle? The answer, yes — at least partially.
As part of this study, we also wrote up a case series of five patients who were LMHR or near-LMHR. These patients all exhibited extraordinary increases in LDL upon starting a ketogenic diet. And, importantly, all were tested for genetic mutations associated with high LDL and all tested negative, supporting the notion that being a LMHR is not a genetic condition but a metabolic phenomenon.
One patient saw his LDL increase from 116 to 665 mg/dL (no surprise, he was the leanest).
All of the patients refused, or were intolerant of, statins and instead opted to reintroduce a moderate amount of carbohydrate, ~50 – 100 grams, in order to transition from a very low-carb ketogenic diet to a diet that was still low-carb (<130 grams net carbs per day).
Impressively, all participants saw their LDL drop by at least 100 mg/dL, with larger drops occurring on those with high levels. The patient who saw his LDL increase to 665 mg/dL exhibited a 480 mg/dL drop in LDL by doing nothing more than adding about a small, sweet potato’s worth of carbs per day.
Stop and think about that for a second. In this context, a sweet potato per day could drop LDL by almost 500 mg/dL!
This is only step one, putting the LMHR phenomenon on the map. This paper suggests that LMHR are real and, if I do say so myself, really interesting!
In my opinion, no true student of health and/or medicine can observe this phenomenon and not be intrigued.
But what this paper does not do is explain the “how.” It likewise can’t evaluate the risk. Those are the subjects of upcoming projects.
This paper was just the first domino...
This paper describes a phenomenon. It does not explain the mechanism nor comment on risk.
Saturated fat intake was not measured; however, it seems highly unlikely variations in saturated fat intake can explain the findings as this would assume that, across the study sample of 548 people, lean people and those with good metabolic health preferentially and reliably consumed more saturated fat.
The phenomenon is likely metabolic, not genetic. This is supported by at least three lines of evidence in this study:
If you found this blog interesting and/or you think this line of research is important, my team and I would appreciate if you go directly to the paper, download it, and try to give it a read. Downloads really help the article metrics and will help to further amplify the discussion around this important phenomenon.
For a list of selected podcasts, videos, and media releases that cover this paper, please see the links below (Updated January 28, 2022):
Podcasts:
YouTube
Other Media:
This is the easiest ever Keto Pigs in Blanket recipe (or mini sausage rolls as we call them in the UK).
You only need 3 ingredients — sausages, mozzarella and almond flour (our simplified fat head dough). Plus we are using herbed butter to add extra flavor.
These piggies are the perfect bite-sized snack for any dinner party, game night or the next Super Bowl. Everyone will love them!
You can serve these sausage bites as they are, warm or cold, with mustard, sugar-free ketchup or pizza sauce.
You can easily convert this recipe by adding 2 oz (57 g) of full-fat cream cheese in the shredded mozzarella before microwaving it, and then swapping the almond flour for either 6 tablespoons (48 g/1.7 oz) of coconut flour or 8 tablespoons (57 g/2 oz) of flax meal. Tried and tested!
Hands-on: 10 minutes
Overall: 20 - 25 minutes
Total Carbs | 4.2 | grams |
Fiber | 1.2 | grams |
Net Carbs | 3.1 | grams |
Protein | 15.5 | grams |
Fat | 25.4 | grams |
of which Saturated | 10 | grams |
Energy | 301 | kcal |
Magnesium | 38 | mg (10% RDA) |
Potassium | 131 | mg (7% EMR) |
Macronutrient ratio: Calories from carbs (4%), protein (21%), fat (75%)
Making muffins in a blender is so easy! This recipe is based on my Keto Vanilla Blender Muffins but without coconut flour and with the addition of pumpkin puree, pumpkin pie spice and chocolate chips.
These keto muffins are made in a blender producing very smooth batter that will produce fluffy muffins with a delicious crust on top. And don't skip the protein powder, it will replace the missing gluten! Although there are 5 eggs to make 12 muffins, these muffins do not taste eggy at all. You need all those eggs to make these muffins fluffy!
You can enjoy these muffins for breakfast with a cup of tea, coffee or Hot Mocha, and or as an after-dinner treat.
Hands-on: 10 minutes
Overall: 30 minutes
Total Carbs | 7 | grams |
Fiber | 2.8 | grams |
Net Carbs | 4.2 | grams |
Protein | 10.3 | grams |
Fat | 17.6 | grams |
of which Saturated | 5.2 | grams |
Energy | 216 | kcal |
Magnesium | 65 | mg (16% RDA) |
Potassium | 282 | mg (14% EMR) |
Macronutrient ratio: Calories from carbs (8%), protein (19%), fat (73%)
I adore this chicken liver pate! It's one of the most flavorful recipes I've ever made and I tested and fine-tuned it for maximum flavor and creaminess.
The perfect balance of flavors come from lightly caramelized onion with fragrant garlic, fresh herbs such as sage, thyme and/or rosemary, bay leaf, allspice, nutmeg, butter and brandy. We're using chicken livers which have a mild flavor. You can also use turkey livers which are just as mild, creamy and delicious.
This pate will be a favorite on any party dinner table served alongside crunchy vegetables such as endive leaves, carrots, bell peppers and cucumbers, or as a dip with Keto Crackers. You can also serve this low-carb pate on hot buttered toast made from our Quick Keto Bread or Quick Keto White Bread.
Hands-on: 30 minutes
Overall: 2 hours 30 minutes
Total Carbs | 0.8 | grams |
Fiber | 0.1 | grams |
Net Carbs | 0.7 | grams |
Protein | 5.1 | grams |
Fat | 18.8 | grams |
of which Saturated | 11.3 | grams |
Energy | 195 | kcal |
Magnesium | 6 | mg (2% RDA) |
Potassium | 81 | mg (4% EMR) |
Macronutrient ratio: Calories from carbs (1%), protein (11%), fat (88%)
This recipe combines the flavors of a classic Bloody Mary cocktail with Shakshuka. It's my tasty twist on one of my absolute favorite breakfast meals that works just as well for lunch and dinner!
We've got sweet tomatoes, crisp-tender celery, mushrooms for bulk and extra nutrition, Worcestershire sauce for umami and lemon juice for zing. You can optionally add a few drops of Tabasco for extra heat.
Top tip: Use duck eggs instead of chicken eggs for extra protein and much bigger egg yolks. Enjoy!
Hands-on: 10 minutes
Overall: 30 minutes
Total Carbs | 15.5 | grams |
Fiber | 5.9 | grams |
Net Carbs | 9.6 | grams |
Protein | 16.5 | grams |
Fat | 30.6 | grams |
of which Saturated | 6 | grams |
Energy | 393 | kcal |
Magnesium | 47 | mg (12% RDA) |
Potassium | 918 | mg (46% EMR) |
Macronutrient ratio: Calories from carbs (10%), protein (17%), fat (73%)